The Southern Greece wine region is situated on the mainland of Greece and includes regions such as Peloponnese, Kefalonia, and Crete. The climate is Mediterranean with hot, dry summers and mild winters, and the terrain is hilly and mountainous. The primary grape varieties grown in this region include Agiorgitiko, Moschofilero, Assyrtiko, and Robola.

The wines produced here are known for their complexity and depth of flavor, with red wines typically being full-bodied and rich, while white wines tend to be crisp and aromatic. The region is particularly renowned for its dry red wines, with the Agiorgitiko grape being the star player.

In Peloponnese, the red Agiorgitiko grape is prominent, producing full-bodied, fruity wines. In Crete, the white grape varieties Vilana and Vidiano are used to produce crisp, aromatic wines. In Kefalonia, the Robola grape is the most prominent, producing white wines with high acidity and minerality.